Media / Science Center

Media/
Science Center

Videos

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Pain Week 2023

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Dr. Dart introducing MPAR overdose protection

Podcasts

22:34

Drug Discovery World – Dr Lynn Kirkpatrick explains PF614-MPAR

12:12

Stock Day Podcast – Dr. Lynn Kirkpatrick talks about TAAP, MPAR and pain relief products

Abstracts & Manuscripts

March 2024
Clinical evaluation of PF614, a novel TAAP prodrug of oxycodone, versus OxyContin in a multi-ascending dose study with a bioequivalence arm in healthy volunteers.
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February 2024
A Novel Trypsin Activated Abuse Protected (TAAP™) ER Oxycodone Prodrug with Overdose Protection
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March 2024
Preventing Prescription Drug Overdoses, Clinical development of Trypsin-Activated Abuse Deterrent (TAAP) Opioids with Overdose Protection
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October 2023
Development of an extended release nafamostat formulation for prescription drug overdose protection. 
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September 2023
PF614-MPAR: A Novel Trypsin Activated Abuse Protected (TAAP™) Extended-Release Oxycodone Prodrug with Overdose Protection. In: Symposium on Severe Pain, Next Generation Solutions – PF614 / PF614-MPAR. 
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September 2023
PF614-MPAR: A Novel Trypsin Activated Abuse Protected (TAAP™) Extended-Release Oxycodone Prodrug with Overdose Protection.
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September 2023
PF614-MPAR: A Novel Trypsin Activated Abuse Protected (TAAP™) Extended-Release Oxycodone Prodrug with Overdose Protection.
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September 2023
Intranasal and Oral Human Abuse Potential (HAP) Studies with PF614: A Novel Trypsin Activated Abuse Protected (TAAP) Oxycodone Prodrug. 
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September 2023
Intranasal and Oral Human Abuse Potential (HAP) Studies with PF614: A Novel Trypsin Activated Abuse Protected (TAAP) Extended-Release Oxycodone Prodrug.
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July 2023
Development of a Multi-Pill Abuse Resistant Extended-Release Formulation to Prevent Opioid Overdose.
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June 2023
Intranasal Human Abuse Potential of PF614: A Novel ‘Next Generation’ Trypsin Activated Abuse Protected (TAAP) Opioid.
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February 2023
MPAR: A Chemical Approach to Opioid Overdose Protection.
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May 2022
The Next Generation Opioid Products for Moderate-Severe Pain
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November 2019
Nonclinical Safety Assessment of PF614, a Novel TAAP Prodrug of Oxycodone
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May 2017
First-in-human pharmacokinetics & safety study of PF614: orally activated oxycodone prodrug. 
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May 2017
First-in-human pharmacokinetics & safety study of PF614, orally activated oxycodone prodrug
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January 2017
In vitro and in vivo assessment of the abuse potential of PF614, a novel BIO-MD™ prodrug of oxycodone
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2012
First in man evaluation of PF329
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